Furan-2-boronic acid → Ethyl 6-(furan-2-yl)imidazo[1,2-a]pyridine-2-carboxylate

HRID 1878488Notes

Reaction equation

HRID 1878488 reaction equation
C([Si](C(C)C)(C(C)C)N1[CH:9]=[CH:8][C:7]([C:10]2[CH:11]=[CH:12][C:13]3[N:14]([CH:16]=[C:17]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[N:18]=3)[CH:15]=2)=C1)(C)C.[O:30]1C=CC=[C:31]1B(O)O>>[O:30]1[CH:31]=[CH:9][CH:8]=[C:7]1[C:10]1[CH:11]=[CH:12][C:13]2[N:14]([CH:16]=[C:17]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[N:18]=2)[CH:15]=1

Participants

3

Reactant 2

HCID 2734357Furan-2-boronic acidHCID 44136203Ethyl 6-[1-(triisopropylsilyl)-1H-pyrrol-3-yl]imidazo[1,2-a]pyridine-2-carboxylate

Product 1

HCID 44136206Ethyl 6-(furan-2-yl)imidazo[1,2-a]pyridine-2-carboxylate

Procedure

This product is prepared under conditions similar to those described for the preparation of Intermediate 15 (step 15.1), replacing the 1-(triisopropylsilyl)pyrrole-3-boronic acid with furan-2-boronic acid.

Workup

  1. customThis product is prepared under conditions similar to

Sources & evidence

ORD record
ord-632ae02f64ad4424b2cc9b276d5000eb
Source dataset
uspto-grants-2012_11
Patent number
US08314109B2

Reaction notes

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