HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-2-fluorotoluene → Methyl N-(4-fluoro-3-methylphenyl)piperidine-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-2-fluorotoluene | HCID 123527 | — |
| Reactant | Methyl isonipecotate | HCID 424914 | — |
| Product | Methyl N-(4-fluoro-3-methylphenyl)piperidine-4-carboxylate | HCID 59023366 | — |
Reaction Steps
starting with 10.6 g (74.0 mmol) of methyl piperidine-4-carboxylate and 4.67 g (24.7 mmol) of 5-bromo-2-fluorotoluene, the general procedure [E] gives 2.74 g (40% of theory) of product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08314113B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-6fea9c9e023a4d10aa16dcd7af1664c6 |
| Source note | uspto-grants-2012_11 |