反应详情

There was dissolved, in 1,4-dioxane (2 mL), 5,7-dichloro-3-phenyl-pyrazolo-[1,5-a]pyrimidine (47.7 mg, 0.181 mM), then morpholine (31.6 μL, 0.362 mM) was added to the solution and the resulting mixture was stirred at room temperature for 30 minutes. The solvent was distilled off from this reaction mixture, the resulting residue was diluted with water and extracted with methylene chloride. The extracts thus obtained were combined, dried over anhydrous sodium sulfate, the solvent was then distilled off, and the resulting solid was washed with methanol to thus obtain the title compound (46.8 mg, yield: 82%).

1. distillationThe solvent was distilled off from this reaction mixture
2. additionthe resulting residue was diluted with water
3. extractionextracted with methylene chloride
4. customThe extracts thus obtained
5. dry with materialdried over anhydrous sodium sulfate
6. distillationthe solvent was then distilled off
7. washthe resulting solid was washed with methanol