反应详情

5,7-Dichloro-pyrazolo[1,5-a]pyrimidine (400 mg, 2.13 mM) was dissolved in 1,4-dioxane (8 mL), then morpholine (372 μL, 4.26 mM) was added to the solution and the mixture was stirred at room temperature for 30 minutes. The solvent was distilled off from the reaction mixture, the resulting residue was diluted with water and extracted with methylene chloride. The extracts thus obtained were combined, dried over anhydrous sodium sulfate and the solvent was then distilled off to give the title compound (461 mg, yield: 91%).

1. distillationThe solvent was distilled off from the reaction mixture
2. additionthe resulting residue was diluted with water
3. extractionextracted with methylene chloride
4. customThe extracts thus obtained
5. dry with materialdried over anhydrous sodium sulfate
6. distillationthe solvent was then distilled off