Ethanol → HCID 76814766, compound

Participants

Reaction Conditions

Reaction Steps

There was suspended, in ethanol (2 mL), 5-chloro-2-(4-methoxy-phenyl)-7-morpholin-4-yl-pyrazolo[1,5-a]pyrimidine (64.8 mg, 0.188 mM) and then potassium carbonate (28.6 mg, 0.198 mM) and hydrazine monohydrate (91.2 μL, 1.88 mM) were added to the suspension. This suspension was stirred at 150° C. for 25 minutes under the irradiation with microwaves. This reaction liquid was diluted with a saturated aqueous common salt solution and then extracted with ethyl acetate. The extracts thus obtained were combined, dried over anhydrous sodium sulfate and the solvent was then distilled off. The resulting residue was suspended in ethanol (2 mL), then acetic acid (5.0 μL, 0.087 mM) and 3-methyl-benzaldehyde (22.1 μL, 0.188 mM) were added to the suspension and the mixture was stirred at room temperature for one hour. This reaction mixture was filtered and the resulting solid was purified by the NH-silica gel column chromatography (methylene chloride) to thus give the title compound (54.6 mg, overall yield of these two steps: 66%).

Provenance & Evidence