1-(2-Hydroxyethyl)piperazine → HCID 86659721, compound

HRID 1878559Notes

Reaction equation

HRID 1878559 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[N:5]2[N:9]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:11]=[C:4]2[N:3]=1.[OH:18][CH2:19][CH2:20][N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[Cl:1][C:2]1[CH:7]=[C:6]([N:24]2[CH2:25][CH2:26][N:21]([CH2:20][CH2:19][OH:18])[CH2:22][CH2:23]2)[N:5]2[N:9]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:11]=[C:4]2[N:3]=1

Participants

3

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 49761343HCID 49761343, compound

Product 1

HCID 86659721HCID 86659721, compound

Procedure

There was dissolved, in 1,4-dioxana (3 mL), 5,7-dichloro-2-phenyl-pyrazolo-[1,5-a]pyrimidine (50.4 mg, 0.191 mM), then 1-(2-hydroxyethyl)-piperazine (46 μL, 0.382 mM) was added to the solution and the mixture was stirred at room temperature for one hour. The solvent was distilled off from this reaction mixture and the resulting solid was washed with ethyl acetate to thus give the title compound in a quantitative yield.

Workup

  1. distillationThe solvent was distilled off from this reaction mixture
  2. washthe resulting solid was washed with ethyl acetate

Sources & evidence

ORD record
ord-a872563a50704455ae358a0b497b1786
Source dataset
uspto-grants-2012_11
Patent number
US08314098B2

Reaction notes

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