Morpholine → HCID 86659726, compound

HRID 1878572Notes

Reaction equation

HRID 1878572 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[N:5]2[N:9]=[C:10]([C:12]3[CH:13]=[N:14][C:15]([N:18]4[CH2:23][CH2:22][O:21][CH2:20][CH2:19]4)=[CH:16][CH:17]=3)[CH:11]=[C:4]2[N:3]=1.[NH:24]1[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1>O1CCOCC1.O>[Cl:1][C:2]1[CH:7]=[C:6]([N:24]2[CH2:29][CH2:28][O:27][CH2:26][CH2:25]2)[N:5]2[N:9]=[C:10]([C:12]3[CH:13]=[N:14][C:15]([N:18]4[CH2:23][CH2:22][O:21][CH2:20][CH2:19]4)=[CH:16][CH:17]=3)[CH:11]=[C:4]2[N:3]=1

Participants

5

Reactant 2

HCID 8083MorpholineHCID 86659727HCID 86659727, compound

Product 1

HCID 86659726HCID 86659726, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

The resulting 5,7-dichloro-2-(6-morpholin-4-yl-pyridin-3-yl)-pyrazolo[1,5-a]-pyrimidine was dissolved in 1,4-dioxane (4 mL), morpholine (500 μL, 5.74 mM) was added to the solution and then the mixture was stirred at room temperature for one hour. The solvent was distilled off from this reaction mixture, the residue obtained was diluted with water, the precipitated solid was recovered through filtration and then dried under reduced pressure to thus give the title compound (59.6 mg, overall yield of these three steps: 5.1%).

Workup

  1. distillationThe solvent was distilled off from this reaction mixture
  2. customthe residue obtained
  3. filtrationthe precipitated solid was recovered through filtration
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-7fee533854ae4e5f9faa82433bd82a55
Source dataset
uspto-grants-2012_11
Patent number
US08314098B2

Reaction notes

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