Hydrazine hydrate (1:1) → HCID 70999566, compound

Participants

Reaction Steps

There was suspended, in 1,4-dioxane (24 mL), 5-chloro-2-(6-methyl-pyridin-3-yl)-7-morpholin-4-yl-pyrazolo[1,5-a]-pyrimidine (0.79 g, 2.4 mM) prepared in the preceding step 1, then hydrazine monohydrate (1.2 mL, 24 mM) was added to the suspension and the mixture was stirred for 15 hours, while refluxing the same with heating. After the stirring operation, the reaction liquid was concentrated, the concentrate was diluted with water and then extracted with ethyl acetate. The resulting extracts were combined, dried over anhydrous sodium sulfate and then the solvent was distilled off to thus give a crude product of the title compound (210 mg, yield: 27%).

Provenance & Evidence