Glycine methyl ester → HCID 44193862, compound

Participants

Reaction Steps

(4-{5-[6-(6-Methyl-pyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-pyridin-3-yl}-benzylamino)-acetic acid methyl ester is prepared by an analogous method to that for methyl-(4-{5-[2-(6-methyl-pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-pyridin-3-yl}-benzyl)-amine (Example 39) by replacing 4-{5-[2-(6-Methyl-pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-pyridin-3-yl}-benzaldehyde (Intermediate 58) with 4-{5-[6-(6-methyl-pyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-3-yl}-benzaldehyde (Intermediate 185) and methylamine hydrochloride with amino-acetic acid methyl ester (Rare Chemicals GmbH, Kiel, Germany).

Provenance & Evidence