Pyridine-2-carbonitrile → Methyl Picolinimidate

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Reaction Steps

Pyridine-2-carbonitrile (Sigma-Aldrich, St. Louis, USA) (1 eq, 190 mmol, 20 g) is dissolved in MeOH (150 ml), then NaOMe (5.4 M in MeOH, 1.1 eq, 209 mmol, 38.7 ml) is added. The resulting mixture is stirred for 16 h at r.t. The solvents are removed in vacuo, then water is added, and the resulting aqueous mixture is extracted with DCM. The organic layer is dried with MgSO4, filtered, and the solvent is removed in vacuo yielding the title compound; [M+H]+=138.

Provenance & Evidence