Boron tribromide → HCID 68761217, compound

Participants

Reaction Steps

To a solution of 3-benzyloxy-N-(5-bromo-pyridin-3-yl)-propionamide (Intermediate 31) (1 eq, 8.1 mmol, 2.8 g) in DCM (100 ml) at 0° C., boron tribromide (1 M in DCM, 1.1 eq, 8.9 mmol, 8.9 ml) is added within 10 min. The mixture is allowed to warm up to r.t. and stirred for 1 h at this temperature. The mixture is filtered, the solid residue is washed with DCM, and dried giving the title compound; [M+H]+=326.

Provenance & Evidence