Acetyl chloride → HCID 68938130, compound

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Reaction Steps

To a solution of 5-bromo-1′,2′,3′,6′-tetrahydro-[3,4′]bipyridinyl (Intermediate 214) (1 eq, 0.523 mmol, 125 mg) in DCM (5 ml) at 0° C. is added TEA (1.1 eq, 0.575 mmol, 0.08 ml). Then acetyl chloride (1.1 eq, 0.575 mmol, 0.041 ml) is added and the resulting mixture is stirred for 20 h at r.t. Additional TEA (1.1 eq, 0.575 mmol, 0.08 ml) and acetyl chloride (1.1 eq, 0.575 mmol, 0.041 ml) are added and stirring is continued for another 1.5 h. The mixture is diluted with DCM and washed with 10% aqueous K2CO3 solution. The organic layer is dried over MgSO4, filtered, and the solvent is removed under reduced pressure giving the title compound; [M+H]+=281/283.

Provenance & Evidence