2-Bromoethanol → HCID 68737629, compound

Participants

Reaction Steps

To a solution of 1-[4-(5-bromo-pyridin-3-yl)-phenyl]-1-methyl-ethylamine (Intermediate 229) (1 eq, 1.72 mmol, 500 mg) in DMF (10 ml) is added NaH (1.2 eq, 2.06 mmol, 82 mg) and the resulting mixture is stirred for 30 min at r.t. Then 2-bromoethanol (Sigma-Aldrich, St. Louis, USA) (2 eq, 3.43 mmol, 0.24 ml) is added, and the mixture is heated at 100° C. for 4 h. 2 M aqueous NaOH is added, and the mixture is extracted with DCM.

Provenance & Evidence