3-Bromo-5-phenylpyridine → HCID 67432589, compound

HRID 1878635Notes

Reaction equation

HRID 1878635 reaction equation
Br[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:7]=1.[CH2:14]([N:18]1[CH2:26][C:25]2[C:20](=[CH:21][CH:22]=[C:23](B(O)O)[CH:24]=2)[C:19]1=[O:30])[CH2:15][CH2:16][CH3:17]>>[CH2:14]([N:18]1[CH2:26][C:25]2[C:20](=[CH:21][CH:22]=[C:23]([C:2]3[CH:3]=[N:4][CH:5]=[C:6]([C:8]4[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=4)[CH:7]=3)[CH:24]=2)[C:19]1=[O:30])[CH2:15][CH2:16][CH3:17]

Participants

3

Reactant 2

HCID 27629043-Bromo-5-phenylpyridineHCID 67430881HCID 67430881, compound

Product 1

HCID 67432589HCID 67432589, compoundYield 14%

Procedure

As described for Example 23 starting from 3-bromo-5-phenylpyridine (50 mg, 0.214 mmol, commercially available) and 2-butyl-1-oxoisoindolin-5-ylboronic acid (49.8 mg, 0.214 mmol, s. above). Yield 14% (10 mg).

Sources & evidence

ORD record
ord-ca6eff42c43543c193880fde23193557
Source dataset
uspto-grants-2012_11
Patent number
US08314120B2

Reaction notes

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