HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2-chloro-N-(4-chlorophenyl)oxazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-Chloroaniline | HCID 7812 | — |
| Reactant | Ethyl 2-chlorooxazole-4-carboxylate | HCID 2763184 | — |
| Product | 2-chloro-N-(4-chlorophenyl)oxazole-4-carboxamide | HCID 68804152 | — |
Reaction Steps
Prepared from ethyl 2-chlorooxazole-4-carboxylate (83.5 mg, 0.475 mmol) and 4-chloroaniline (60.5 mg, 0.475 mmol) as described in Example 154A: 1H NMR (500 MHz, DMSO-D6) δ ppm 7.37-7.45 (m, 2H), 7.81-7.89 (m, 2H), 8.91 (s, 1H), 10.45 (s, 1H) MS (DCI/NH3) m/z=274 (M+NH4)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08314119B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-d66bf9184ff343c59a0e63264a587f79 |
| Source note | uspto-grants-2012_11 |