Phosphoric Acid → HCID 86621457, compound

HRID 1878682Notes

Reaction equation

HRID 1878682 reaction equation
[C:1]1([C:7]2[S:11][C:10]([O:12][C@@H:13]3[CH:20]4[CH2:21][N:16]5[CH2:17][CH:18]([CH2:22][CH:14]3[CH2:15]5)[CH2:19]4)=[N:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[P:23](=[O:27])([OH:26])([OH:25])[OH:24]>CO>[P:23]([OH:27])([OH:26])([OH:25])=[O:24].[C:1]1([C:7]2[S:11][C:10]([O:12][C@@H:13]3[CH:20]4[CH2:21][N:16]5[CH2:17][CH:18]([CH2:22][CH:14]3[CH2:15]5)[CH2:19]4)=[N:9][N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 1004Phosphoric Acid2×HCID 249878751026134-63-32×

Product 1

HCID 86621457HCID 86621457, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

(4s)-4-(5-Phenyl-1,3,4-thiadiazol-2-yloxy)-1-azatricyclo[3.3.1.13,7]decane free base (20 mg, 0.064 mmol) was dissolved in 1.0 mL of methanol. Meanwhile, 5 μL of 85% phosphoric acid (0.073 mmol) was diluted with 245 μL methanol. The phosphoric acid solution was then added dropwise to the (4s)-4-(5-phenyl-1,3,4-thiadiazol-2-yloxy)-1-azatricyclo[3.3.1.13,7]decane free base solution while stirring. The vial was removed from the stir plate after the addition. The dihydrogen phosphate anhydrate crystallized upon standing.

Workup

  1. customThe vial was removed from the stir plate
  2. additionafter the addition
  3. customThe dihydrogen phosphate anhydrate crystallized

Sources & evidence

ORD record
ord-1d57bad76eb541d7af0d3f16231caa31
Source dataset
uspto-grants-2012_11
Patent number
US08314119B2

Reaction notes

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