Benzoyl chloride → N-(1-(1-(7-Methoxyquinolin-4-yloxy)-2-methylpropan-2-yl)-6-oxo-1,6-dihydropyridin-3-yl)benzamide

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 5-amino-1-(1-(7-methoxyquinolin-4-yloxy)-2-methylpropan-2-yl)pyridin-2(1 H)-one (33 mg, 97 μmol) in CH2Cl2 (3 mL) and tBuOH (1 mL) at 0° C. under nitrogen was added DIEA (17 μl, 97 μmol) followed by a solution of benzoyl chloride (11 μl, 97 μmol) in CH2Cl2 (0.5 mL). The reaction mixture was stirred for 24 h at 23° C. and partitioned between CH2Cl2 (10 mL) and 5% NaHCO3 (5 mL). The organic was dried over MgSO4, concentrated onto dry silica, and purified on silica (12 g) eluting with 0-5% MeOH/CH2Cl2. MS (ESI pos. ion) m/z (MH+): 444. Calc'd exact mass for C26H25N3O4: 443. 1H NMR (400 MHz, Chloroform-d) 8 ppm 1.77 (s, 6 H) 3.89 (s, 3 H) 4.97 (s, 2 H) 6.15 (d, J=5.67 Hz, 1 H) 6.60 (d, J=9.59 Hz, 1H) 7.08 (dd, J=9.19, 2.54 Hz, 1 H) 7.29-7.58 (m, 8H) 7.66 (d, J=2.74 Hz, 1 H) 7.85-7.92 (m, 3 H) 8.02-8.18 (m, 2 H).

Provenance & Evidence