反应详情

温度

75 °C

A mixture of 2-(2-(6-oxo-3-phenylpyridazin-1(6H)-yl)ethyl)isoindoline-1,3-dione (2.1 g, 6.1 mmol) and hydrazine (10 mL, 10.0 mmol) (THF) in MeOH (40 mL) was heated to 75° C. A clear solution was formed. After overnight (18 h), the slurry was cooled to room temperature and was filtered and washed with MeOH. The filtrate was concentrated and washed with 20% MeOH/CH2Cl2 to give a yellow solid (LCMS indicated the presence of product). The filtrate was concentrated under vacuum and was carried to next step.

1. customA clear solution was formed
2. temperaturethe slurry was cooled to room temperature
3. filtrationwas filtered
4. washwashed with MeOH
5. concentrationThe filtrate was concentrated
6. washwashed with 20% MeOH/CH2Cl2
7. customto give a yellow solid (LCMS
8. concentrationThe filtrate was concentrated under vacuum