HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → tert-Butyl 2-(3-chloro-6-oxopyridazin-1(6H)-yl)ethylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 6-Chloropyridazin-3-ol | HCID 252828 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | tert-Butyl N-(2-bromoethyl)carbamate | HCID 4103526 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | tert-Butyl 2-(3-chloro-6-oxopyridazin-1(6H)-yl)ethylcarbamate | HCID 59843113 | — |
Reaction Steps
A suspension of 6-chloropyridazin-3(2H)-one (2912 mg, 22.3 mmol), tert-butyl 2-bromoethylcarbamate (5000 mg, 22.3 μmol), and K2CO3 (9251 mg, 66.9 mmol) was stirred in DMF (40 mL) overnight at 23° C. The mixture was partioned between CH2Cl2 (200 mL) and 5% NaHCO3 (50 mL). The organic layer was dried with brine and MgSO4, concentrated to a solid from toluene under reduced pressure. MS (ESI pos. ion) m/z (MH+): 274 Calc'd exact mass for C11H16ClN3O3: 273.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08314087B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-16c096172e454721815ee0f329cb584b |
| Source note | uspto-grants-2012_11 |