Potassium Carbonate → 2-(4-(tert-Butyldimethylsilyloxy)phenethyl)-6-phenylpyridazin-3(2H)-one

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Reaktionsschritte

A mixture of (4-(2-bromoethyl)phenoxy)(tert-butyl)dimethylsilane (142 mg, 450 μmol), 6-phenyl-3(2h)-pyridazinone (116 mg, 676 μmol), and potassium carbonate (187 mg, 1351 μmol) in DMF (1.5 mL) was stirred at 40° C. for 18 h. The mixture was partioned between CH2Cl2 (20 mL) and 5% NaHCO3 (10 mL). The organic layer was dried with satd. NH4Cl and over MgSO4, and dried to a film from toluene under reduced pressure. The residue was purified on 40 g silica eluting with 0>2.5% MeOH/CH2Cl2. MS (ESI pos. ion) m/z (MH+): 407 (MH+). Calc'd exact mass for C24H30N2O2Si: 406.

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