HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(Methylsulfonyl)-6-(1-propylpiperidin-4-YL)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | 18-Crown-6 | HCID 28557 | — |
| Reactant | 4-[2-Fluoro-3-(methylsulfonyl)phenyl]-1-propylpiperidine | HCID 11514933 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(Methylsulfonyl)-6-(1-propylpiperidin-4-YL)benzonitrile | HCID 11544037 | — |
Reaction Steps
Preparation according to Example 7: 4-[2-fluoro-3-(methylsulfonyl)phenyl]-1-propylpiperidine (0.2 g, 0.67 mmol), N,N-dimethylformamide (30 ml), sodium cyanide (0.82 g, 1.67 mmol) and 18-crown-6-ether (5 mg). Yield: 0.06 g (29%). The amine was converted to the hydrochloric acid salt and recrystallized from ethanol/diethyl ether: MS m/z (relative intensity, 70 eV) 306 (M+, 3), 279 (6), 278 (16), 277 (bp), 198 (5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08314126B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-69f47f5310dd45dfae90c792efe8537c |
| Source note | uspto-grants-2012_11 |