HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 4-[2-Fluoro-3-(methylsulfonyl)phenyl]-1-methylpiperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-[2-Fluoro-3-(methylsulfonyl)phenyl]piperidine | HCID 57448038 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-[2-Fluoro-3-(methylsulfonyl)phenyl]-1-methylpiperidine | HCID 57448043 | — |
Reaction Steps
To a solution of 4-[2-fluoro-3-(methylsulfonyl)-phenyl]-piperidine (0.02 g, 0.078 mmol) in acetonitrile (2 ml) was added potassium carbonate (0.02 g, 0.14 mmol) and iodomethane (0.0047 ml, 0.078 mmol). The mixture was stirred at ambient temperature for 1 h. MS m/z (relative intensity, 70 eV) 271 (M+, 66), 270 (bp), 192 (9), 133 (13) 97 (32).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08314126B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-997013351a0b4ff9bd73509f024bf3c4 |
| Source note | uspto-grants-2012_11 |