HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 4-[2-Fluoro-3-(methylsulfonyl)phenyl]-1-(3,3,3-trifluoro-propyl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1,1,1-Trifluoro-3-iodopropane | HCID 156165 | — |
| Reactant | 4-[2-Fluoro-3-(methylsulfonyl)phenyl]piperidine | HCID 57448038 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-[2-Fluoro-3-(methylsulfonyl)phenyl]-1-(3,3,3-trifluoro-propyl)piperidine | HCID 67533208 | — |
Reaction Steps
Preparation according to Example 1: 4-[2-fluoro-3-(methylsulfonyl)phenyl]piperidine (0.02 g, 0.078 mmol), acetonitrile (2 ml), potassium carbonate (0.02 g, 0.14 mmol), 1,1,1-trifluoro-3-iodopropane (0.010 ml, 0.082 mmol). MS m/z (relative intensity, 70 eV) 353 (M+, 11), 271 (15), 270 (bp), 152 (14) 133 (9).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08314126B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-304d77034c724deaa3ead1a27fc6aeb7 |
| Source note | uspto-grants-2012_11 |