2-Butyn-1-ol → HCID 67533140, compound

HRID 1878976Notes

Reaction equation

HRID 1878976 reaction equation
[CH2:1]([N:3]1[CH2:8][CH2:7][CH:6]([C:9]2[C:10](F)=[C:11]([C:15](=[O:17])[CH3:16])[CH:12]=[CH:13][CH:14]=2)[CH2:5][CH2:4]1)[CH3:2].C([OH:23])C#CC.[K].CC(C)([O-])C>CS(C)=O>[CH2:1]([N:3]1[CH2:8][CH2:7][CH:6]([C:9]2[C:10]([OH:23])=[C:11]([C:15](=[O:17])[CH3:16])[CH:12]=[CH:13][CH:14]=2)[CH2:5][CH2:4]1)[CH3:2]

Participants

5

Reactant 3

HCID 129912-Butyn-1-olHCID 11536115HCID 11536115, compoundHCID 50987170Potassium tertbutoxide

Product 1

HCID 67533140HCID 67533140, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Preparation according to Example 5: 1-[3-(1-ethylpiperidin-4-yl)-2-fluorophenyl]ethanone (12 mg, 0.048 mmol), dimethylsulfoxide (1 ml), 2-butyn-1-ol (6.7 mg, 0.096 mmol), potassium-tertbutoxide (11 mg, 0.096 mmol). MS m/z (relative intensity, 70 eV) 247 (M+, 57), 232 (bp), 218 (28), 147 (24) 84 (67).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-ba412ff74e3c48039cb2f75cf155647b
Source dataset
uspto-grants-2012_11
Patent number
US08314126B2

Reaction notes

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