HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 3-(1-Ethylpiperidin-4-YL)phthalonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | 18-Crown-6 | HCID 28557 | — |
| Reactant | Ordopidine | HCID 11701939 | — |
| Product | 3-(1-Ethylpiperidin-4-YL)phthalonitrile | HCID 67533242 | — |
Reaction Steps
Preparation according to Example 31: 1-ethyl-4-[2-fluoro-3-(methylsulfonyl)phenyl]-piperidine (1.06 g, 3.72 mmol), N,N-dimethylformamide (30 ml), sodium cyanide (0.7 g, 14.0 mmol) and 18-crown-6-ether (5 mg). Yield: 0.35 g. MS m/z (relative intensity, 70 eV) 239 (M+, 3), 225 (17), 224 (bp), 154 (6), 71 (5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08314126B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-ad4ab210e469424ca8534b49d0dfc928 |
| Source note | uspto-grants-2012_11 |