Lawesson's reagent → HCID 25068634, compound

Participants

Reaction Conditions

Reaction Steps

Succinic acid 4-carbamoyl-phenyl ester 2-{2-[8-(2,2-dimethyl-butyryloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydro-naphthalen-1-yl]-ethyl}-6-oxo-tetrahydro-pyran-4-yl ester (2) (0.35 g, 0.000548 mol) and Lawesson reagent (0.221 g, 0.000548 mol) were dissolved in 30 ml of anhydrous benzene. The reaction was warmed to 50° C. and stirred for 6 h. The solvent was removed under reduced pressure; the crude residue was purificated by silica gel column (dichloromethane/methyl alcohol 9.5:0.5) to furnish 35 mg of the pure compound 3 (10% yield).

Provenance & Evidence