Water → 4-methyl-2-[6-((E)-3-phenyl-propenyl)-pyrazin-2-yl]-thiazole-5-carboxylic acid benzylamide

Participants

Reaction Steps

Part A. To a solution of 2-(6-iodo-pyrazin-2-yl)-4-methyl-thiazole-5-carboxylic acid benzylamide (80 mg, 0.18 mmol, 1.0 equiv) in dimethyl ether (1 mL) was added Na2CO3 (38 mg, 0.36 mmol, 2.0 equiv), trans-3-phenylpropen-1-yl boronic acid (73 mg, 0.45 mmol, 2.5 equiv), PdCl2(dppf) (1.3 mg, 0.02 mmol, 0.1 equiv) and water (0.1 mL) in a sealed tube. The reaction vessel was immersed in an oil bath preheated to 60° C. After stirring for 3 hr, the reaction mixture was cooled and the solvent was removed in vacuo. The crude product was purified by column chromatography [SiO2, methanol/dichloromethane, 0:100 to 10:90, v/v] to give 4-methyl-2-[6-((E)-3-phenyl-propenyl)-pyrazin-2-yl]-thiazole-5-carboxylic acid benzylamide (39 mg, 50%); MS (M+H)+=427.1, Rt=1.70 min.

Provenance & Evidence