HuagongsheHuagongshe Chemistry Print Report · For research reference only
Betahistine → HCID 24955066, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Betahistine | HCID 2366 | — |
| Reactant | 1-(4-fluorophenyl)-N-methylmethanamine | HCID 736860 | — |
| Reactant | 2-(6-Iodo-pyrazin-2-yl)-4-methyl-thiazole-5-carboxylic acid 4-fluoro benzylamide | HCID 86645558 | — |
| Product | HCID 24955066 | HCID 24955066 | 75% |
Reaction Steps
Following the procedure described in Example 14, making variations as required to replace 4-fluoro-N-methyl-benzylamine with methyl-(2-pyridin-2-yl-ethyl)-amine to react with 2-(6-iodo-pyrazin-2-yl)-4-methyl-thiazole-5-carboxylic acid 4-fluoro benzylamide, the title compound was obtained in 75% yield. 1H NMR (400 MHz, CD2Cl2) δ 8.40-8.52 (m, 2H), 8.03 (s, 1H), 7.36-7.43 (m, 3H), 7.11-7.35 (m, 3H), 7.00-7.10 (m, 2H), 4.55 (d, J=4.0 Hz, 2H), 4.00-4.15 (m, 2H), 3.15-3.40 (m, 2H), 3.12 (bs, 3H), 2.70 (s, 3H); MS (ES+) m/z 463.1 (M+1), Rt=1.39 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08314138B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-6152b6f7e509426cb949e24d7b0ba44b |
| Source note | uspto-grants-2012_11 |