3-(Methylaminomethyl)pyridine → HCID 59489545, compound

Participants

Reaction Steps

Following the procedure described in Example 14, making variations as required to replace 4-fluoro-N-methyl-benzylamine with methyl-pyridin-3-ylmethyl-amine to react with 2-(6-iodo-pyrazin-2-yl)-4-methyl-thiazole-5-carboxylic acid 4-fluoro benzylamide, the title compound was obtained in 78% yield. 1H NMR (400 MHz, CD2Cl2) δ 8.58-8.65 (m, 2H), 8.45-8.49 (m, 1H), 8.11 (s, 1H), 7.62-7.68 (m, 1H), 7.29-7.37 (m, 2H), 7.22-7.28 (m, 1H), 6.98-7.08 (m, 2H), 6.35 (bs, 1H), 4.84 (s, 2H), 4.54 (d, J=8.0 Hz, 2H), 3.18 (s, 3H), 2.69 (s, 3H); MS (ES+) m/z 449.2 (M+1), Rt=1.32 min.

Provenance & Evidence