HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methylpyridine-4-methylamine → HCID 59489558, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methylpyridine-4-methylamine | HCID 81436 | — |
| Reactant | 1-(4-fluorophenyl)-N-methylmethanamine | HCID 736860 | — |
| Reactant | 2-(6-Iodo-pyrazin-2-yl)-4-methyl-thiazole-5-carboxylic acid 4-fluoro benzylamide | HCID 86645558 | — |
| Product | HCID 59489558 | HCID 59489558 | 78% |
Reaction Steps
Following the procedure described in Example 14, making variations as required to replace 4-fluoro-N-methyl-benzylamine with methyl-pyridin-4-ylmethyl-amine to react with 2-(6-iodo-pyrazin-2-yl)-4-methyl-thiazole-5-carboxylic acid 4-fluoro-benzylamide, the title compound was obtained in 78% yield. 1H NMR (400 MHz, CD2Cl2) δ 8.63 (s, 1H), 8.51 (d, J=8.0 Hz, 2H), 8.14 (s, 1H), 7.27-7.36 (m, 4H), 6.99-7.08 (m, 2H), 6.18 (bs, 1H), 4.86 (s, 2H), 4.54 (d, J=4.0 Hz, 2H), 3.21 (s, 3H), 2.68 (s, 3H); MS (ES+) m/z 449.2 (M+1), Rt=1.30 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08314138B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-d3a876feb847405392919072e515503f |
| Source note | uspto-grants-2012_11 |