Sodium Hydroxide → HCID 68491522, compound

Participants

Reaction Steps

Part C. To a solution of 2-(6-{[2-(4-fluoro-phenoxy)-ethyl]-methyl-amino}-pyrazin-2-yl)-4-methyl-thiazole-5-carboxylic acid ethyl ester (220 mg, 0.53 mmol) in tetrahydrofuran (8 mL) was added 1N NaOH (8 mL). The resulting reaction mixture was heated to reflux for 14 hr. The solvent was removed in vacuo, and the residue was neutralized to pH 4-5 with 10% HCl. The resulting precipitate was filtered and dried to afford 2-(6-{[2-(4-fluoro-phenoxy)-ethyl]-methyl-amino}-pyrazin-2-yl)-4-methyl-thiazole-5-carboxylic acid in 92% yield.

Provenance & Evidence