Benzylamine → HCID 59489543, compound

Participants

Reaction Steps

Part C. Following the procedure described in Example 1 (Part A), making variations as required to replace benzylamine with 3-(aminomethyl)-pyridine to react with 2-{6-[(4-fluoro-benzyl)-methyl-amino]-pyrazin-2-yl}-4-methyl-thiazole-5-carboxylic acid, the title compound was obtained in 82% yield. 1H NMR (400 MHz, CD2Cl2) δ 8.55-8.60 (m, 2H), 8.48 (d, J=4.0 Hz, 1H), 8.06 (s, 1H), 7.65-7.70 (m, 1H), 7.21-7.28 (m, 3H), 6.95-7.02 (m, 2H), 6.25 (bs, 1H), 4.78 (s, 2H), 4.56 (d, J=4.0 Hz, 2H), 3.11 (s, 3H), 2.69 (s, 3H); MS (ES+) m/z 449.2 (M-1-1), Rt=1.33 min.

Provenance & Evidence