Benzylamine → HCID 24955065, compound

Participants

Reaction Steps

Following the procedure described in Example 1 (Part A), making variations as required to replace benzylamine with cyclopropane-methyl-amine to react with 2-{6-[(4-fluoro-benzyl)-methyl-amino]-pyrazin-2-yl}-4-methyl-thiazole-5-carboxylic acid, the title compound was obtained in 75% yield. 1H NMR (400 MHz, CD2Cl2) δ 8.58 (s, 1H), 8.05 (s, 1H), 7.25-7.31 (m, 2H), 6.98-7.05 (m, 2H), 5.95 (bs, 1H), 4.82 (s, 2H), 3.21-3.26 (m, 2H), 3.15 (s, 3H), 2.70 (s, 3H), 1.00-1.10 (m, 1H), 0.50-0.57 (m, 2H), 0.22-0.28 (m, 2H); MS (ES+) m/z 412.3 (M+1), Rt=1.52 min.

Provenance & Evidence