4-Chloro-2-fluorobenzyl bromide → HCID 24951495, compound

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The title compound was prepared from 4-methyl-2-(2H-pyrazol-3-yl)-thiazole-5-carboxylic acid (pyridin-3-ylmethyl)-amide and 1-bromomethyl-4-chloro-2-fluoro-benzene as described in Example 49 and isolated as a white solid (0.075 g; 51% yield). 1H NMR (400 MHz, CDCl3) δ 8.61 (s, 1H), 8.56-8.58 (m, 1H), 7.71 (d, J=8 Hz, 1H), 7.46 (d, J=4 Hz, 1H), 7.26-7.31 (m, 1H), 7.10-7.17 (m, 3H), 6.85 (s, 1H), 6.07-6.15 (m, 1H), 5.36 (s, 2H), 4.62 (d, J=8 Hz, 2H), 2.75 (s, 3H). MS (M+H)+=442.1; Rt=1.35 min; HRMS (M+H)+=442.09.

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