4-(Bromomethyl)benzonitrile → HCID 24951497, compound

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The title compound was prepared from 4-methyl-2-(2H-pyrazol-3-yl)-thiazole-5-carboxylic acid (pyridin-3-ylmethyl)-amide and 4-bromomethyl-benzonitrile as described in Example 49 and isolated as a white solid (0.065 g, 46% 1H NMR (400 CDCl3) δ 3.60 (s, 1H), 8.55-8.57 (m, 1H), 7.71 (d, J=8 Hz, 1H), 7.64 (d, J=8 Hz, 2H), 7.46 (s, 1H), 7.26-7.31 (m, 3H), 6.90 (d, J=4 Hz, 1H), 6.11-6.16 (m, 1H), 5.41 (s, 2H), 4.63 (d, J=8 Hz, 2H), 2.75 (s, 3H); MS (M+H)+=415.2; Rt=1.15 min; HRMS (M+H)+=415.14.

Provenance & Evidence