1-(4-(bromomethyl)phenyl)-1H-1,2,4-triazole → 4-methyl-2-[1-(4-[1,2,4]triazol-1-yl-benzyl)-1H-pyrazol-3-yl]-thiazole-5-carboxylic acid (pyridin-3-ylmethyl)amide

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Reaction Steps

The title compound was prepared from 4-methyl-2-(2H-pyrazol-3-yl)-thiazole-5-carboxylic acid (pyridin-3-ylmethyl)-amide and 1-(4-bromomethyl-phenyl)-1H-[1,2,4]-triazole as described in Example 49 and isolated as a white solid (76 mg, 51% yield). 1H NMR (400 MHz, CDCl3) δ 8.62 (s, 1H), 8.53-8.57 (m, 1H), 8.54 (s, 1H), 8.10 (s, 1H), 7.66-7.71 (m, 3H), 7.45 (bs, 1H), 7.39 (d, J=8 Hz, 1H), 7.37-7.41 (m, 1H), 6.88 (s, 1H), 6.05-6.12 (m, 1H), 5.41 (s, 2H), 4.63 (d, J=4 Hz, 2H), 2.75 (s, 3H); MS (M+H)+=457.2; Rt=1.08 min; HRMS (M+H)+=457.16.

Provenance & Evidence