4-Fluorobenzyl bromide → HCID 24956489, compound

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The title compound was prepared from 4-methyl-2-(2H-pyrazol-3-yl)-thiazole-5-carboxylic acid (pyridin-3-ylmethyl)-amide and 1-bromomethyl-4-fluoro-benzene as described in Example 49 and isolated as a white solid (0.072 g, 51% yield). 1H NMR (400 MHz, CDCl3) δ 8.61 (s, 1H), 8.54-8.57 (m, 2H), 7.71 (d, J=8 Hz, 1H), 7.38 (d, J=4 Hz, 1H), 7.21-7.32 (m, 3H), 7.02-7.06 (m, 2H), 6.84 (d, J=2 Hz, 1H), 6.12-6.15 (m, 1H), 5.31 (s, 2H), 4.63 (d, J=8 Hz, 2H), 2.75 (s, 3H); MS (M+H)+=408.3; Rt=1.22 min; HRMS (M+H)+=408.13.

Provenance & Evidence