1-(Bromomethyl)-4-(trifluoromethyl)benzene → 4-methyl-2-[1-(4-trifluoromethyl-benzyl)-1H-pyrazol-3-yl]-thiazole-5-carboxylic acid (pyridin-3-ylmethyl)amide

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The title compound was prepared from 4-methyl-2-(2H-pyrazol-3-yl)-thiazole-5-carboxylic acid (pyridin-3-ylmethyl)-amide and bromomethyl-4-trifluoromethyl-benzene as described in Example 49 and isolated as yellow solid (0.075 g, 50% yield). 1H NMR (400 MHz, CDCl3) δ 8.61 (s, 1H), 8.56 (d, J=4 Hz, 2H), 7.70 (d, J=4 Hz, 1H), 7.61 (d, J=8 Hz, 2H), 7.44 (d, J=4 Hz, 1H), 7.26-7.36 (m, 3H), 6.88 (d, J=2 Hz, 1H), 6.13 (t, J=5 Hz, 1H), 5.41 (s, 2H), 4.63 (d, J=8 Hz, 2H), 2.75 (s, 3H); MS (M+H)+=458.1; Rt=1.35 min; HRMS (M+H)+=458.13.

Provenance & Evidence