1-(Bromomethyl)-4-(1,1-dimethylethyl)benzene → HCID 59489561, compound

HRID 1879194Notes

Reaction equation

HRID 1879194 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][NH:8][C:9]([C:11]2[S:15][C:14]([C:16]3[NH:17][N:18]=[CH:19][CH:20]=3)=[N:13][C:12]=2[CH3:21])=[O:10])[CH:2]=1.Br[CH2:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]([CH3:33])([CH3:32])[CH3:31])=[CH:26][CH:25]=1>>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][NH:8][C:9]([C:11]2[S:15][C:14]([C:16]3[CH:20]=[CH:19][N:18]([CH2:23][C:24]4[CH:29]=[CH:28][C:27]([C:30]([CH3:33])([CH3:32])[CH3:31])=[CH:26][CH:25]=4)[N:17]=3)=[N:13][C:12]=2[CH3:21])=[O:10])[CH:2]=1

Participants

3

Reactant 2

HCID 878361-(Bromomethyl)-4-(1,1-dimethylethyl)benzeneHCID 866455594-methyl-2-(2H-pyrazol-3-yl)-thiazole-5-carboxylic acid (pyridin-3-ylmethyl)-amide

Product 1

HCID 59489561HCID 59489561, compound

Procedure

The title compound was prepared from 4-methyl-2-(2H-pyrazol-3-yl)-thiazole-5-carboxylic acid (pyridin-3-ylmethyl)-amide and 1-bromomethyl-4-tert-butyl-benzene as described in Example 49 and isolated as a yellow solid (0.080 g, 53% yield). 1H NMR (400 MHz, CDCl3) δ 8.61 (s, 1H), 8.56 (d, J=4 Hz, 1H), 7.71 (d, J=8 Hz, 1H), 7.36-7.40 (m, 3H), 7.26-7.30 (m, 1H), 7.20 (d, J=8 Hz, 2H), 6.82 (d, J=2 Hz, 1H), 6.09-6.14 (m, 1H), 5.31 (s, 2H), 4.63 (d, J=8 Hz, 2H), 2.75 (s, 3H), 1.30 (s, 9H); MS (M+H)+=445.9; Rt=1.47 min; HRMS (M+H)+=446.20.

Sources & evidence

ORD record
ord-3e6062b6d2764cc98babed9290d5985c
Source dataset
uspto-grants-2012_11
Patent number
US08314138B2

Reaction notes

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