3,5-Difluorobenzyl bromide → 2-[1-(3,5-difluoro-benzyl)-1H-pyrazol-3-yl]-4-methyl-thiazole-5-carboxylic acid (pyridin-3-ylmethyl)amide

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Reaction Steps

The title compound was prepared from 4-methyl-2-(2H-pyrazol-3-yl)-thiazole-5-carboxylic acid (pyridin-3-ylmethyl)-amide and 1-bromomethyl-3,5-difluoro-benzene as described in Example 49 and isolated as a white solid (0.071 mg, 51% yield). 1H NMR (400 MHz, CDCl3) δ 8.61 (s, 1H), 8.56 (d, J=4 Hz, 1H), 7.71 (d, J=8 Hz, 1H), 7.45 (d, J=2 Hz, 1H), 7.28-7.34 (m, 1H), 6.89 (d, J=2 Hz, 1H), 6.70-6.79 (m, 3H), 6.12-6.18 (m, 1H), 5.32 (s, 2H), 4.63 (d, J=8 Hz, 2H), 2.75 (s, 3H); MS (M+H)+=425.9; Rt=1.25 min; HRMS (M+H)+=426.12.

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