Neophyl chloride → 4-methyl-2-[1-(2-methyl-2-phenyl-propyl)-1H-pyrazol-3-yl]-thiazole-5-carboxylic acid (pyridin-3-ylmethyl)amide

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The title compound was prepared from 4-methyl-2-(2H-pyrazol-3-yl)-thiazole-5-carboxylic acid (pyridin-3-ylmethyl)-amide and (2-chloro-1,1-dimethyl-ethyl)benzene as described in Example 49 and isolated as a white solid, (0.025 mg, 20% yield). 1H NMR (400 MHz, CDCl3) δ 8.65 (bs, 1H), 8.57 (d, J=4 Hz, 1H), 7.78 (d, J=8 Hz, 1H), 7.23-7.49 (m, 6H) 6.69 (d, J=2 Hz, 1H), 6.63 (d, J=2 Hz, 1H), 6.12-6.18 (bm, 1H), 4.64 (d, J=4 Hz, 2H), 4.28 (s, 2H), 2.75 (s; 3H), 1.40 (s, 6H); MS (M+H)+=432.2; Rt=1.39 min; HRMS (M+H)+=432.19.

Provenance & Evidence