4-Fluoroaniline → HCID 24951500, compound

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The title compound was prepared from methanesulfonic acid 2-(3-{4-methyl-5-[(pyridin-3-ylmethyl)-carbamoyl]-thiazol-2-yl}-pyrazol-1-yl)-ethyl ester and 4-fluoro-phenylamine as describe in Example 77 and isolated as a white solid (0.032 g, 53% yield). 1H NMR (400 MHz, CDCl3) δ 8.63 (s, 1H), 8.56 (d, J=4 Hz, 1H), 7.72 (d, J=8 Hz, 1H), 7.39 (d, J=2 Hz, 1H), 7.28-7.34 (m, 1H), 6.89 (t, J=8 Hz, 2H), 6.83 (d, J=2 Hz, 1H), 6.51-6.56 (m, 2H), 6.09 (bs, 1H), 4.65 (d, J=8 Hz, 2H), 4.47 (t, J=6 Hz, 2), 3.58-3.63 (m, 2H), 2.76 (s, 3H); MS (M+H)+=436.9; Rt=1.20 min; HRMS (M+H)+=437.12.

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