4-Fluorobenzenesulfonyl chloride → HCID 59489546, compound

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The title compound was prepared from 2-[1-(2-amino-ethyl)-1H-pyrazol-3-yl]-4-methyl-thiazole-5-carboxylic acid (pyridin-3-ylmethyl)-amide) and 4-fluoro-benzenesulfonyl chloride as describe in Example 81 and isolated as a white solid (0.052 g, 37% yield). 1H NMR (400 MHz, CDCl3) δ 8.62 (s, 1H), 8.56 (d, J=4 Hz, 1H), 7.83-7.87 (m, 2H), 7.73 (d, J=8 Hz, 1H), 7.42 (d, J=2 Hz, 1H), 7.27-7.33 (m, 1H), 7.16 (t, J=8 Hz, 2H), 6.79 (d, J=2 Hz, 1H), 6.09-6.14 (bm, 1H), 5.36 (bs, 1H), 4.64 (d, J=8 Hz, 2H), 4.25-4.29 (m, 2H), 3.47 (bs, 2H), 2.74 (s, 3H); MS (M+H)+=500.8; Rt=1.08 min; HRMS (M+H)+=501.12.

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