(2-Bromoethyl)cyclopropane → HCID 59489535, compound

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The title compound was prepared from 4-methyl-2-(2H-pyrazol-3-yl)thiazole-5-carboxylic acid 4-fluoro-benzylamide and (2-bromo-ethyl)cyclopropane as describe in Example 83 and isolated as a white solid (0.045 g, 38% yield). 1H NMR (400 MHz, CDCl3) δ 7.44 (d, J=2 Hz, 1H), 7.29-7.35 (m, 2H), 7.05 (t, J=8 Hz, 2H), 6.80 (d, J=2 Hz, 1H), 5.96-6.01 (bm, 1H), 4.57 (d, J=4 Hz, 2H), 4.23 (t, J=7 Hz, 2H), 2.75 (s, 3H), 1.78 (q, J=7 Hz, 2H), 0.58-0.68 (m, 1H), 0.40-0.48 (m, 2H), 0.0-0.04 (m, 2H); MS (M+H)+=385.2; Rt=1.48 min; HRMS (M+H)+=385.15.

Provenance & Evidence