3-(2-Bromoethyl)indole → HCID 59489562, compound

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Reaction Steps

The title compound was prepared from 4-methyl-2-(2H-pyrazol-3-yl)thiazole-5-carboxylic acid 4-fluoro-benzylamide and 3-(2-bromo-ethyl)-1H-indole as describe in Example 83 and isolated as a yellow solid (0.056 g, 40% yield). 1H NMR (400 MHz, CDCl3) δ 8.01 (bs, 1H), 7.56 (d, J=8 Hz, 1H), 7.31-7.38 (m, 2H), 7.20-7.25 (m, 1H), 7.10-7.16 (m, 2H), 6.81 (d, J=2 Hz, 1H), 6.70 (d, J=2 Hz, 1H), 5.99-6.04 (m, 1H), 4.59 (d, J=4 Hz, 2H), 4.45 (t, J=7 Hz, 2H), 3.35 (t, J=7 Hz, 2H), 2.76 (s, 3H); MS (M+H)+=460.2; Rt=1.47 min; HRMS (M+H)+=460.16.

Provenance & Evidence