(2-Bromo-2-propanyl)benzene → HCID 24952220, compound

HRID 1879223Notes

Reaction equation

HRID 1879223 reaction equation
[CH2:1]([NH:8][C:9]([C:11]1[S:15][C:14]([C:16]2[NH:17][N:18]=[CH:19][CH:20]=2)=[N:13][C:12]=1[CH3:21])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[C:23]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)([CH3:25])[CH3:24]>CCCCCCC.C(O)(C)C>[CH2:1]([NH:8][C:9]([C:11]1[S:15][C:14]([C:16]2[CH:20]=[CH:19][N:18]([CH2:24][C@@H:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH3:25])[N:17]=2)=[N:13][C:12]=1[CH3:21])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 12492649(2-Bromo-2-propanyl)benzeneHCID 24955764HCID 24955764, compound

Product 1

HCID 24952220HCID 24952220, compound

Reagents, catalysts & solvents 1

HCID 21225753Isopropanol heptaneSolvent

Procedure

The title compound was prepared from 4-methyl-2-(2H-pyrazol-3-yl)-thiazole-5-carboxylic acid benzylamide and 2-(bromo-1-methyl-ethyl)-benzene as described in Example 90 and isolated by chiral separation (90/10, heptane/isopropyl alcohol). 1H NMR (400 MHz, CDCl3) δ 7.35-7.41 (m, 5H), 7.20-7.35 (m, 3H), 7.14 (d, J=4 Hz, 2H), 7.08 (d, J=2 Hz, 1H), 6.75-6.82 (bs, 1H), 6.66 (d, J=2 Hz, 1H), 4.60 (d, J=8 Hz, 2H), 4.20-4.32 (m, 2H), 3.38-3.46 (m, 1H), 2.73 (s, 3H), 1.30 (d, J=4 Hz, 3H); MS (M+H)+=417.2; Rt=1.32 min; HRMS (M+H)+=417.17.

Sources & evidence

ORD record
ord-bd484baf2cf947f4a58d5fa2023f9c1a
Source dataset
uspto-grants-2012_11
Patent number
US08314138B2

Reaction notes

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