HCID 68492755, compound → HCID 24951499, compound

HRID 1879228Notes

Reaction equation

[F:1][C:2]1[CH:23]=[CH:22][C:5]([CH2:6][NH:7][C:8]([C:10]2[S:14][C:13]([C:15]3[NH:16][N:17]=[C:18]([CH3:20])[CH:19]=3)=[N:12][C:11]=2[CH3:21])=[O:9])=[CH:4][CH:3]=1.[F:24][C:25]1[CH:30]=[CH:29][C:28]([CH2:31][CH2:32]N2C(C)=CC(I)=N2)=[CH:27][CH:26]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][NH:7][C:8]([C:10]2[S:14][C:13]([C:15]3[CH:19]=[C:18]([CH3:20])[N:17]([CH2:32][CH2:31][C:28]4[CH:29]=[CH:30][C:25]([F:24])=[CH:26][CH:27]=4)[N:16]=3)=[N:12][C:11]=2[CH3:21])=[O:9])=[CH:22][CH:23]=1

Participants

Reactant 2

HCID 68492755HCID 68492755, compound

HCID 178423361HCID 178423361, compound

Product 1

HCID 24951499HCID 24951499, compound

Procedure

The title compound was prepared from 4-methyl-2-[5-methyl-2H-pyrazol-3-yl]-thiazole-5-carboxylic acid 4-fluoro-benzylamide and 1-[2-(4-fluoro-phenyl)-ethyl]-3-iodo-5-methyl-1H-pyrazole as described in Example 93 and isolated as a white solid (0.035 g, 14% yield). 1H NMR (400 MHz, CDCl3) δ 7.23-7.27 (m, 2H), 6.98 (t, J=8 Hz, 2H), 6.82-6.90 (m, 4H), 6.41 (s, 1H), 5.92-6.00 (bm, 1H), 4.50 (d, J=4 Hz, 2H), 4.15 (t, J=6 Hz, 2H), 3.05 (t, J=6, 2H), 2.68 (s, 3H), 1.84 (s, 3H); MS (M+H)+=452.9; Rt=1.56 min; HRMS (M+H)+=453.16.

Sources & evidence

ORD record: ord-e3a2e3f7ef1b43d59e6a393e7042ef1e
Source dataset: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08314138B2

Reaction notes

Loading…