Lithium hydroxide, monohydrate → HCID 44221525, compound

Participants

Reaction Conditions

Reaction Steps

Lithium hydroxide monohydrate (6 eq.) was added to a stirred mixture of methyl N-(2,2-difluorohept-6-en-1-yl)-L-valinate 73 in THF and water (2/1 v/v, 0.013 M) and the mixture was stirred at 60° C. After 1 h, it was cooled to RT and THF was evaporated under reduced pressure. Aqueous 1N HCl was added until pH=5, and the aq. phase was extracted with EtOAc. Drying over Na2SO4, filtration and evaporation under reduced pressure afforded the title compound that was used in the following step without further purification. MS (ES+) m/z 250 (M+H)+.

Provenance & Evidence