Imidazole → HCID 58005152, compound

Participants

Reaction Steps

A 0.5 M solution of (3′-bromobiphenyl-3-yl)methanol 94 in DCM was added to a 10 min. prestirred suspension of triphenylphosphine resin (1.6 eq.), Br2 (1.6 eq.) and 0.25 M solution of imidazole (1.7 eq.) in DCM. The reaction mixture was gently stirred at RT for 3 h. The resin was then filtered off and washed with DCM, the filtrate was evaporated to dryness to afford the title compound 95 (78% crude yield) as a brown oil. The material was used in the following step without further purification. 1H NMR (400 MHz, DMSO-d6, 300 K) δ 7.90 (s, 1H), 7.86-7.82 (m, 1H), 7.76-7.70 (m, 1H), 7.70-7.65 (m, 1H), 7.65-7.60 (m, 1H), 7.55-7.49 (m, 2H), 7.47 (d, J 7.8, 1H), 4.81 (s, 2H).

Provenance & Evidence