Hydrochloric Acid → HCID 86637108, compound

Participants

Reaction Steps

1-tert-Butyl 2-methyl (2S,4R)-4-[(3′-bromobiphenyl-3-yl)methoxy]pyrrolidine-1,2-dicarboxylate 96 (1.0 eq.) was dissolved at 0° C. in a 4M solution of HCl in dioxane (3.0 eq.) to give a 1.0 M solution. The reaction mixture was stirred at RT for 2 h then the solvent was evaporated under reduced pressure to afford the title compound 97 as a white foam (96%). 1H NMR (400 MHz, DMSO-d6, 300 K) δ 10.33-9.33 (bs, 1H), 7.89 (s, 1H), 7.77-7.71 (m, 2H), 7.67 (d, J 7.7, 1H), 7.62 (d, J 7.7, 1H), 7.54-7.43 (m, 3H), 4.63 (s, 2H), 4.55 (dd, J 10.7, 7.4 Hz, 1H), 4.41 (bs, 1H), 3.81 (s, 3H), 3.51-3.40 (m, 2H), 2.59-2.51 (m, 1H), 2.27-2.16 (m, 1H). MS (ES) m/z 390, 392 (M+H)+.

Provenance & Evidence